Education only · provider review required
Research pathway · 08
Menopause & perimenopause, explained
The largest group of people researching hormones and "longevity" are women in perimenopause and menopause — and the honest answer is that the best-evidenced options here are approved medicines, not peptides. This page sorts it out.
Free · about 10 minutes · reviewed by a licensed physician
What people are usually asking
The questions are practical: hot flushes, sleep, mood, weight change, libido, joint aches, brain fog. Many of these overlap with thyroid problems, iron deficiency and depression, which is why a provider tests before treating.
This pathway covers approved hormone therapy, the compounded alternatives that are marketed heavily, the non-hormonal options, and the peptide claims — with the evidence status on each.
Peptides discussed in this context
Listed for education. Inclusion is not a recommendation, and none of these is an FDA-approved treatment for the question above.
Menopausal hormone therapy (oestrogen & progesterone)
Menopausal hormone therapy
FDA-approved products · strongest evidence for symptoms
Read the page → 02Hormone pellet therapy
Compounded pellets
Not FDA-approved · society statements caution
Read the page → 03Thyroid basics
Thyroid
Approved treatment · rule out first
Read the page → 04DHEA
DHEA / prasterone
Supplement · one approved prescription form
Read the page → 05Testosterone therapy
Testosterone in women
Off-label · limited evidence (see page)
Read the page → 06Semaglutide
GLP-1 medicines
FDA-approved for weight management
Read the page → 07Kisspeptin
Kisspeptin research
Human physiology studies · not approved
Read the page →Where the evidence stands
Hormone therapy has large randomised trials and decades of follow-up; for suitable women under 60 or within ten years of menopause, professional societies describe benefits as outweighing risks. Non-hormonal options — SSRIs/SNRIs, gabapentin, fezolinetant (approved 2023) — have controlled trials for hot flushes. Compounded pellets and "bioidentical" blends lack that evidence. Peptides have none for menopause.
Status reflects published research context only and is not a statement of safety, efficacy, or suitability for any person.
Questions worth bringing to a provider
The intake is where individual questions belong. These are the ones that tend to make that conversation useful.
- Are my symptoms menopausal, thyroid-related, or something else — and what test tells us?
- Am I a candidate for approved hormone therapy, and which route (patch, gel, oral, local)?
- Is anything in my history — clots, breast cancer, migraine with aura — a contraindication?
- Which of the non-hormonal options have real evidence for hot flushes and sleep?
- What would make you say no?
What happens if you start an intake
The intake asks about your cycle history, symptoms, family history, clotting and cancer history, and current medicines. A licensed provider reviews it and tells you whether hormone therapy, non-hormonal options, testing, or a referral is the right next step. Free, about 10 minutes, no obligation.
Frequently asked questions
Is there a peptide for menopause?
No. No peptide has evidence for menopausal symptoms. Approved hormone therapy and several non-hormonal medicines do. Peptide marketing aimed at menopause should be treated with caution.
Are bioidentical hormones safer?
FDA-approved products include bioidentical oestradiol and progesterone. Compounded versions are not safer and are less consistently dosed.
Does this page recommend hormone therapy?
No. It explains what is approved and where evidence stands; whether it is appropriate for you is a provider's decision after intake.
Next step
Next step: a 3-minute confidential intake, reviewed by a licensed provider. No treatment is promised or implied.
Free · about 10 minutes · reviewed by a licensed physician
General education · Not medical advice · Provider approval required